In previous studies it has been shown that forskolin and noradrenaline stimulate cAMP production in in vitro preparations of rat brain tissue, and that baclofen can inhibit the forskolin stimulation, and augment the noradrenaline stimulation. The purpose of the present study was to determine the pharmacological profile of this GABAb receptor mediated response, and investigate its physiological relevance by using in vivo microdialysis in awake freely moving rats, and by determining the class of cells in which the response occurs. Thus, in a cross-chopped rat cortical slice preparation, it was confirmed that (-)Baclofen inhibited forskolin stimulated adenylyl cyclase activity and augmented noradrenaline stimulated adenylyl cyclase activity. T...
In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen depressed the rate of spont...
There is an increasing interest in the development of nondopaminergic pharmacotherapies for cocaine ...
The potential efficacy of GABA(B) receptor agonists in the treatment of pain, drug addiction, epilep...
(gamma)-Aminobutyric acid (GABA), a neurotransmitter in the mammalian central nervous system, influe...
The ability of 2,6 Di-tert-butyl-4-(-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930), a positive allos...
A number of studies have shown that activation of gamma-aminobutyric acid(B) (GABA(B)) receptors pot...
We studied the effects of the positive allosteric modulator GS39783 on GABA(B) receptors at a bioche...
Previous studies have shown that GABA(B) receptors facilitate cyclic AMP formation in brain slices l...
In rat neocortical slices maintained in Mg(2+)-free Krebs medium, the gamma-aminobutyric acid (GABA(...
Evidence recently provided has suggested a specific involvement of the GABAergic system in modulatin...
In rat neocortical slices maintained in Mg2+-free Krebs medium, the gamma-aminobutyric acid (GABAB) ...
Using grease-gap recording from rat neocortical slices, the GABA(B) receptor agonist baclofen elicit...
Copyright © 2001 Elsevier Science B.V. All rights reserved.In rat neocortical preparations maintaine...
GABA(B) receptors (GABA(B)Rs) mediate slow inhibitory effects on neuronal excitability and synaptic ...
Whole-cell patch clamp recordings were made from ICC neurons in brain slices of 9-16 day old rats. P...
In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen depressed the rate of spont...
There is an increasing interest in the development of nondopaminergic pharmacotherapies for cocaine ...
The potential efficacy of GABA(B) receptor agonists in the treatment of pain, drug addiction, epilep...
(gamma)-Aminobutyric acid (GABA), a neurotransmitter in the mammalian central nervous system, influe...
The ability of 2,6 Di-tert-butyl-4-(-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930), a positive allos...
A number of studies have shown that activation of gamma-aminobutyric acid(B) (GABA(B)) receptors pot...
We studied the effects of the positive allosteric modulator GS39783 on GABA(B) receptors at a bioche...
Previous studies have shown that GABA(B) receptors facilitate cyclic AMP formation in brain slices l...
In rat neocortical slices maintained in Mg(2+)-free Krebs medium, the gamma-aminobutyric acid (GABA(...
Evidence recently provided has suggested a specific involvement of the GABAergic system in modulatin...
In rat neocortical slices maintained in Mg2+-free Krebs medium, the gamma-aminobutyric acid (GABAB) ...
Using grease-gap recording from rat neocortical slices, the GABA(B) receptor agonist baclofen elicit...
Copyright © 2001 Elsevier Science B.V. All rights reserved.In rat neocortical preparations maintaine...
GABA(B) receptors (GABA(B)Rs) mediate slow inhibitory effects on neuronal excitability and synaptic ...
Whole-cell patch clamp recordings were made from ICC neurons in brain slices of 9-16 day old rats. P...
In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen depressed the rate of spont...
There is an increasing interest in the development of nondopaminergic pharmacotherapies for cocaine ...
The potential efficacy of GABA(B) receptor agonists in the treatment of pain, drug addiction, epilep...