Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects the type and magnitude of the immune response in comparison to sustained release from a local depot. PLGA microparticles (MP, volume mean diameter ≈ 112 μm) and nanoparticles (NP, Z-average diameter ≈ 350 nm) co-encapsulating ovalbumin (OVA) and poly(I:C), with comparable antigen (Ag) release characteristics, were prepared and characterized. The immunogenicity of these two distinct particulate vaccines was evaluated in vitro and in vivo. NP were...
AIM: Dendritic cells rapidly capture nanoparticles and induce a potent cellular immune response. It ...
Background: Poly(D, L-lactic-co-glycolic acid) (PLGA) nanoparticles have potential applications as a...
Dendritic cells (DCs) are key players in the initiation of adaptive immune responses and are current...
Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delive...
Polymeric nano/microparticles as vaccine adjuvants have been researched in experimental and clinical...
Polymeric nano/microparticles as vaccine adjuvants have been researched in experimental and clinical...
Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components to dendri...
Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components to dendri...
Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components to dendri...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
Conventional subunit vaccine regimes can be modified in order to stimulate strong immune responses r...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
AIM: Dendritic cells rapidly capture nanoparticles and induce a potent cellular immune response. It ...
Background: Poly(D, L-lactic-co-glycolic acid) (PLGA) nanoparticles have potential applications as a...
Dendritic cells (DCs) are key players in the initiation of adaptive immune responses and are current...
Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delive...
Polymeric nano/microparticles as vaccine adjuvants have been researched in experimental and clinical...
Polymeric nano/microparticles as vaccine adjuvants have been researched in experimental and clinical...
Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components to dendri...
Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components to dendri...
Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components to dendri...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
Conventional subunit vaccine regimes can be modified in order to stimulate strong immune responses r...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
International audienceMucosal immunization is designed to induce strong immune responses at portal o...
AIM: Dendritic cells rapidly capture nanoparticles and induce a potent cellular immune response. It ...
Background: Poly(D, L-lactic-co-glycolic acid) (PLGA) nanoparticles have potential applications as a...
Dendritic cells (DCs) are key players in the initiation of adaptive immune responses and are current...