SUVpeak performance in Lung Cancer: Comparison to Average SUV from 40 Hottest Voxels

The performance of an average standard uptake value (SUV) over a 1-mL-volume sphere within an (18)F-FDG-positive lesion resulting in the highest possible value (SUVpeakW), was compared to that of an average SUV computed from the 40 hottest voxels, irrespective of their location within the lesion (SUVmax-40). METHODS A PET dynamic acquisition performed in 20 lung cancer lesions yielded for each SUV metric its mean value, relative measurement error and repeatability (MEr-R). RESULTS SUVpeakW mean value was significantly 9.66% lower than that of SUVmax-40 (P<0.0001). SUVpeakW and SUVmax-40 MEr-R were significantly lower than MEr-R of SUVmax (the hottest voxel): 9.35-13.21%, 8.84-12.49% versus 13.86-19.59% respectively (95%-CL; P