OBJECTIVE: Rheumatoid arthritis (RA) is a chronic inflammatory disorder of unknown origin. Histone deacetylase (HDA) activity is considered to play a major role in the transcriptional regulation of proinflammatory genes. We undertook this study to investigate the balance of histone acetylase and HDA activity in synovial tissue from RA patients compared with that from patients with osteoarthritis (OA) and normal controls. METHODS: Activity of histone acetylases and HDAs was measured in nuclear extracts of total synovial tissue samples, which were obtained from RA and OA patients undergoing surgical joint replacement, and compared with the activity in synovial tissues from patients without arthritis. Tissue expression of HDAs 1 and 2 was qua...
Background Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in animal mode...
Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have demonstrated anti-inflammatory prop...
Macrophages contribute significantly to the pathology of many chronic inflammatory diseases, includi...
inflammatory disorder of unknown origin. Histone deacetylase (HDA) activity is considered to play a ...
Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joint...
Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in t...
Emerging evidence implicates epigenetic mechanisms in the pathogenesis of rheumatoid arthritis (RA)....
Reduced synovial expression of histone deacetylases (HDACs) is proposed to contribute to pathology i...
Rheumatoid Arthritis or RA disease is a chronic inflammatory and systemic disease associated with br...
OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription...
OBJECTIVES Epigenetic modifications play an important role in the regulation of gene transcription ...
The studies presented in this thesis demonstrate essential roles for histone deacetylase (HDAC) acti...
Objective. Histone deacetylase 1 (HDAC1) is highly expressed in the synovium of RA patients. Thus we...
Abstract Background To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflamm...
Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TN...
Background Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in animal mode...
Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have demonstrated anti-inflammatory prop...
Macrophages contribute significantly to the pathology of many chronic inflammatory diseases, includi...
inflammatory disorder of unknown origin. Histone deacetylase (HDA) activity is considered to play a ...
Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joint...
Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in t...
Emerging evidence implicates epigenetic mechanisms in the pathogenesis of rheumatoid arthritis (RA)....
Reduced synovial expression of histone deacetylases (HDACs) is proposed to contribute to pathology i...
Rheumatoid Arthritis or RA disease is a chronic inflammatory and systemic disease associated with br...
OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription...
OBJECTIVES Epigenetic modifications play an important role in the regulation of gene transcription ...
The studies presented in this thesis demonstrate essential roles for histone deacetylase (HDAC) acti...
Objective. Histone deacetylase 1 (HDAC1) is highly expressed in the synovium of RA patients. Thus we...
Abstract Background To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflamm...
Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TN...
Background Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in animal mode...
Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have demonstrated anti-inflammatory prop...
Macrophages contribute significantly to the pathology of many chronic inflammatory diseases, includi...