Highly potent biotoxins like Pseudomonas exotoxin A (ETA) are attractive payloads for tumor targeting. However, despite replacement of the natural cell-binding domain of ETA by tumor-selective antibodies or alternative binding proteins like designed ankyrin repeat proteins (DARPins) the therapeutic window of such fusion toxins is still limited by target-independent cellular uptake, resulting in toxicity in normal tissues. Furthermore, the strong immunogenicity of the bacterial toxin precludes repeated administration in most patients. Site-specific modification to convert ETA into a prodrug-like toxin which is reactivated specifically in the tumor, and at the same time has a longer circulation half-life and is less immunogenic, is therefore ...
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer ther...
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer ther...
Cancer cells have been known to overexpress the epidermal growth factor receptor (EGFR) and hence re...
Highly potent biotoxins like Pseudomonas exotoxin A (ETA) are attractive payloads for tumor targetin...
Highly potent biotoxins like Pseudomonas exotoxin A (ETA) are attractive payloads for tumor targetin...
Fusion toxins used for cancer-related therapy have demonstrated short circulation half-lives, which ...
Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to...
Immunotoxins consist of an antibody or antibody fragment that binds to a specific cell surface struc...
ABSTRACT Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for del...
ABSTRACT Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for del...
Targeted anticancer therapeutics offer the advantage of reducing cytotoxic side effects to normal ce...
Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas...
Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two vir...
Pseudomonas aeruginosa Exotoxin A (ETA) is a 66.6 kDa bacterial toxin comprised of a single polypept...
Background/Aim: Pseudomonas exotoxin (PE) is one of the most widely used toxins in the construction ...
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer ther...
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer ther...
Cancer cells have been known to overexpress the epidermal growth factor receptor (EGFR) and hence re...
Highly potent biotoxins like Pseudomonas exotoxin A (ETA) are attractive payloads for tumor targetin...
Highly potent biotoxins like Pseudomonas exotoxin A (ETA) are attractive payloads for tumor targetin...
Fusion toxins used for cancer-related therapy have demonstrated short circulation half-lives, which ...
Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to...
Immunotoxins consist of an antibody or antibody fragment that binds to a specific cell surface struc...
ABSTRACT Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for del...
ABSTRACT Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for del...
Targeted anticancer therapeutics offer the advantage of reducing cytotoxic side effects to normal ce...
Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas...
Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two vir...
Pseudomonas aeruginosa Exotoxin A (ETA) is a 66.6 kDa bacterial toxin comprised of a single polypept...
Background/Aim: Pseudomonas exotoxin (PE) is one of the most widely used toxins in the construction ...
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer ther...
The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer ther...
Cancer cells have been known to overexpress the epidermal growth factor receptor (EGFR) and hence re...