Treatment efficacy for non-cardiovascular chest pain: a systematic review and meta-analysis

Burgstaller, Jakob M
Jenni, Boris F
Steurer, Johann
Held, Ulrike
Wertli, Maria M

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Publication date

January 2014

DOI

10.1371/journal.pone.0104722

Publisher

Public Library of Science (PLoS)

Abstract

BACKGROUND Non-cardiovascular chest pain (NCCP) leads to impaired quality of life and is associated with a high disease burden. Upon ruling out cardiovascular disease, only vague recommendations exist for further treatment. OBJECTIVES To summarize treatment efficacy for patients presenting with NCCP. METHODS Systematic review and meta-analysis. In July 2013, Medline, Web of Knowledge, Embase, EBSCOhost, Cochrane Reviews and Trials, and Scopus were searched. Hand and bibliography searches were also conducted. Randomized controlled trials (RCTs) evaluating non-surgical treatments in patients with NCCP were included. Exclusion criteria were poor study quality and small sample size (<10 patients per group). RESULTS Thirty eligible RCT's ...