Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1
- Sospedra, Mireia
- Schippling, Sven
- Yousef, Sara
- Jelcic, Ilijas
- Bofill-Mas, Silvia
- Planas, Raquel
- Stellmann, Jan-Patrick
- Demina, Viktoria
- Cinque, Paola
- Garcea, Robert
- Croughs, Therese
- Girones, Rosina
- Martin, Roland
Publication date
September 2014
DOI Publisher
Oxford University Press (OUP) ISSN
1537-6591 Citation count (estimate)
26Abstract
Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation
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