A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown
International audienceAlthough being a primary objective in the management of type 2 diabetes, optim...
Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic ...
Objectives: Type-2 diabetes mellitus, caused by impaired secretion of insulin, is becoming one of th...
A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogu...
A novel molecular scaffold has been synthesized, and its synthesis and incorporation into new analog...
In our efforts to develop second generation DPP-4 inhibitors, we endeavored to identify distinct str...
A novel molecular scaffold has been synthesized, and its incorporation into new analogues of biologi...
AIM: To develop novel, potent, selective and orally active inhibitors of Dipeptidyl Peptidase IV wi...
The present invention is related to novel compounds of the general formula (A), their tautomeric for...
Type II diabetes (T2DM) is considered one of the most prevalent metabolic disorders in the world. It...
Dipeptidyl peptidase IV (DPP-4) is a serine protease that plays a crucial role in glucose metabolism...
Type 2 diabetes mellitus is one of the most common diseases of the 21st century, caused by a sedenta...
BACKGROUND: There has been great interest in determining whether natural products show biological ac...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatm...
<div><h3>Background</h3><p>There has been great interest in determining whether natural products sho...
International audienceAlthough being a primary objective in the management of type 2 diabetes, optim...
Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic ...
Objectives: Type-2 diabetes mellitus, caused by impaired secretion of insulin, is becoming one of th...
A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogu...
A novel molecular scaffold has been synthesized, and its synthesis and incorporation into new analog...
In our efforts to develop second generation DPP-4 inhibitors, we endeavored to identify distinct str...
A novel molecular scaffold has been synthesized, and its incorporation into new analogues of biologi...
AIM: To develop novel, potent, selective and orally active inhibitors of Dipeptidyl Peptidase IV wi...
The present invention is related to novel compounds of the general formula (A), their tautomeric for...
Type II diabetes (T2DM) is considered one of the most prevalent metabolic disorders in the world. It...
Dipeptidyl peptidase IV (DPP-4) is a serine protease that plays a crucial role in glucose metabolism...
Type 2 diabetes mellitus is one of the most common diseases of the 21st century, caused by a sedenta...
BACKGROUND: There has been great interest in determining whether natural products show biological ac...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatm...
<div><h3>Background</h3><p>There has been great interest in determining whether natural products sho...
International audienceAlthough being a primary objective in the management of type 2 diabetes, optim...
Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic ...
Objectives: Type-2 diabetes mellitus, caused by impaired secretion of insulin, is becoming one of th...
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