Human ribosomal gene repeats are distributed among five nucleolar organizer regions (NORs) on the p arms of acrocentric chromosomes. On exit from mitosis, nucleoli form around individual active NORs. As cells progress through the cycle, these mini-nucleoli fuse to form large nucleoli incorporating multiple NORs. It is generally assumed that nucleolar incorporation of individual NORs is dependent on ribosomal gene transcription. To test this assumption, we determined the nuclear location of individual human acrocentric chromosomes, and their associated NORs, in mouse> human cell hybrids. Human ribosomal genes are transcriptionally silent in this context. Combined immunofluorescence and in situ hybridization (immuno-FISH) on three-dimensional...
The nucleus of mammalian cells consists of several structural and functional domains, of which the n...
The nucleolus, the largest sub-nuclear structure, forms around arrays of ribosomal RNA genes, termed...
AbstractBackground: In comparison with many nuclear proteins, the movement of chromatin in nuclei ap...
Human ribosomal gene repeats are distributed among five nucleolar organizer regions (NORs) on the p ...
The short arms of the five acrocentric human chromosomes harbor sequences that direct the assembly a...
In human cells ribosomal genes are organized as clusters called Nucleolus Organizer Regions (NORs) t...
The nucleolus is a large, sub-nuclear domain and the site of ribosome biogenesis. Nucleoli form aro...
AbstractIt is widely accepted that chromosomes occupy more or less fixed positions in mammalian inte...
The short-arms of the five acrocentric human chromosomes contain sequences that direct the assembly ...
The nuclear space is mostly occupied by chromosome territories and nuclear bodies. Although this org...
Nucleolar Organiser Regions (NORs) are comprised of ribosomal gene (rDNA) arrays and adjacent sequen...
The nuclear space is mostly occupied by chromosome territories and nuclear bodies. Although this org...
The nuclear space is mostly occupied by chromosome territories and nuclear bodies. Although this org...
Nucleoli are the sites of ribosome biogenesis and the largest membraneless subnuclear structures. Th...
Human cell nuclei are functionally organized into structurally stable yet dynamic bodies whose cell ...
The nucleus of mammalian cells consists of several structural and functional domains, of which the n...
The nucleolus, the largest sub-nuclear structure, forms around arrays of ribosomal RNA genes, termed...
AbstractBackground: In comparison with many nuclear proteins, the movement of chromatin in nuclei ap...
Human ribosomal gene repeats are distributed among five nucleolar organizer regions (NORs) on the p ...
The short arms of the five acrocentric human chromosomes harbor sequences that direct the assembly a...
In human cells ribosomal genes are organized as clusters called Nucleolus Organizer Regions (NORs) t...
The nucleolus is a large, sub-nuclear domain and the site of ribosome biogenesis. Nucleoli form aro...
AbstractIt is widely accepted that chromosomes occupy more or less fixed positions in mammalian inte...
The short-arms of the five acrocentric human chromosomes contain sequences that direct the assembly ...
The nuclear space is mostly occupied by chromosome territories and nuclear bodies. Although this org...
Nucleolar Organiser Regions (NORs) are comprised of ribosomal gene (rDNA) arrays and adjacent sequen...
The nuclear space is mostly occupied by chromosome territories and nuclear bodies. Although this org...
The nuclear space is mostly occupied by chromosome territories and nuclear bodies. Although this org...
Nucleoli are the sites of ribosome biogenesis and the largest membraneless subnuclear structures. Th...
Human cell nuclei are functionally organized into structurally stable yet dynamic bodies whose cell ...
The nucleus of mammalian cells consists of several structural and functional domains, of which the n...
The nucleolus, the largest sub-nuclear structure, forms around arrays of ribosomal RNA genes, termed...
AbstractBackground: In comparison with many nuclear proteins, the movement of chromatin in nuclei ap...