Aurora kinases play an essential role in orchestrating chromosome alignment, segregation and cytokinesis during mitotic progression, with both aurora-A and B frequently over-expressed in a variety of human malignancies including those of leukaemic origin. Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells whose prognosis is particularly poor and where standard induction therapy has changed little over the past thirty years. This thesis evaluated the effects of AZD1152-hQPA (barasertib-hQPA), a highly selective inhibitor of aurora-B kinase, in AML cell lines and primary samples. Inhibition of phospho-Histone H3 (pHH3) on serine 10 can be used as a biomarker for AZD1152-hQPA activity and an ass...
Ph. D. Thesis.Acute myeloid leukaemia (AML) is a clinically heterogeneous disease driven by somatic ...
Background: Recent studies show the importance of interactions between CD47 expressed on acute myelo...
Acute myelogenous leukemia (AML) is the deadliest of the lymphatic and bone marrow cancers. Patients...
Background Aurora kinases play an essential role in the orchestration of chromosome separation and c...
We investigated the effects of targeting the mitotic regulators aurora kinase A and B in pediatric a...
Aurora B kinase as a chromosomal passenger protein plays multiple roles in regulating mitosis and cy...
The Aurora kinases play an important role in chromosome alignment, segregation, and cytokinesis duri...
BACKGROUND: The overexpression of Aurora A kinase (AurA) has been reported in various malignancies, ...
Aurora kinases are a family of protein kinases that have a key role in multiple stages of mitosis. O...
Internal tandem duplication of FLT3 (FLT3-ITD) is one of the most common somatic mutations in acute ...
The mitotic kinase Aurora B plays a pivotal role in mitosis and cytokinesis and governs the spindle ...
At present, there are no compounds in clinical development in the field of chronic myeloid leukemia ...
Aurora kinases are essential cell cycle regulators for normal cell division. All three members of th...
Background and Aim: A goal of modern cancer research is to reach targeted therapies with drugs havin...
The transcription factor NF-κB can play both a protective and destructive role in cells. NF-κB prote...
Ph. D. Thesis.Acute myeloid leukaemia (AML) is a clinically heterogeneous disease driven by somatic ...
Background: Recent studies show the importance of interactions between CD47 expressed on acute myelo...
Acute myelogenous leukemia (AML) is the deadliest of the lymphatic and bone marrow cancers. Patients...
Background Aurora kinases play an essential role in the orchestration of chromosome separation and c...
We investigated the effects of targeting the mitotic regulators aurora kinase A and B in pediatric a...
Aurora B kinase as a chromosomal passenger protein plays multiple roles in regulating mitosis and cy...
The Aurora kinases play an important role in chromosome alignment, segregation, and cytokinesis duri...
BACKGROUND: The overexpression of Aurora A kinase (AurA) has been reported in various malignancies, ...
Aurora kinases are a family of protein kinases that have a key role in multiple stages of mitosis. O...
Internal tandem duplication of FLT3 (FLT3-ITD) is one of the most common somatic mutations in acute ...
The mitotic kinase Aurora B plays a pivotal role in mitosis and cytokinesis and governs the spindle ...
At present, there are no compounds in clinical development in the field of chronic myeloid leukemia ...
Aurora kinases are essential cell cycle regulators for normal cell division. All three members of th...
Background and Aim: A goal of modern cancer research is to reach targeted therapies with drugs havin...
The transcription factor NF-κB can play both a protective and destructive role in cells. NF-κB prote...
Ph. D. Thesis.Acute myeloid leukaemia (AML) is a clinically heterogeneous disease driven by somatic ...
Background: Recent studies show the importance of interactions between CD47 expressed on acute myelo...
Acute myelogenous leukemia (AML) is the deadliest of the lymphatic and bone marrow cancers. Patients...