Following trauma from high-energy blasts, a population of multipotent progenitor cells (MPCs) can be derived from the debrided muscle tissue. Given the non-intrusive nature of MPC isolation, MPCs represent an attractive clinical alternative to the more widely used mesenchymal stem cells derived from bone marrow and other tissue sources. This dissertation presents work which further defines the utility and limitations of MPCs in applications relevant to the repair of extremity injuries, including angiogenesis, peripheral nerve repair, and bone formation. The secretome of MPCs enhanced in vitro angiogenesis, in a manner dependent on MPC production of vascular endothelial growth factor-A (VEGF). Encapsulated within mechanically tunable inje...
Abstract 1) A variety of stem/progenitor populations have been isolated from human dental tissue ove...
Low back pain affects nearly 85% of the population of the United States, and is associated with a hu...
Background - In the recent wars, 77% of all British casualties received extremity injuries. The crit...
Autologous nerve grafts are the current gold standard for the repair of peripheral nerve injuries. H...
Bone formation occurs through two ossification processes, intramembranous and endochondral. Intramem...
Multipotential stromal cells/ mesenchymal stem cells (MSCs) can regenerate bone and adipose tissues,...
As the prevalence of osteoporosis is expected to increase over the next few decades, the development...
The gold standard for bone regeneration requires harvesting a piece of healthy bone from the patient...
Hyaluronic acid (HA) is a key component of the extracellular matrix known for absorbing water, swell...
Microcurrent therapy (MCT) involves the application of sub-sensory electric current and can promote ...
Limited autologous vascular graft availability and poor patency rates of synthetic grafts for small-...
textThis study investigated the effect of bone marrow derived mesenchymal stem cells (MSCs) in a PEG...
PhD ThesisOsteoarthritis (OA) is a common degenerative disease of articular joints characterised by ...
thesisElevated circulating fatty acids can cause oxidative stress and impair endothelial function, l...
The local release of complexed siRNA from biomaterials enables targeted therapy of specific cells an...
Abstract 1) A variety of stem/progenitor populations have been isolated from human dental tissue ove...
Low back pain affects nearly 85% of the population of the United States, and is associated with a hu...
Background - In the recent wars, 77% of all British casualties received extremity injuries. The crit...
Autologous nerve grafts are the current gold standard for the repair of peripheral nerve injuries. H...
Bone formation occurs through two ossification processes, intramembranous and endochondral. Intramem...
Multipotential stromal cells/ mesenchymal stem cells (MSCs) can regenerate bone and adipose tissues,...
As the prevalence of osteoporosis is expected to increase over the next few decades, the development...
The gold standard for bone regeneration requires harvesting a piece of healthy bone from the patient...
Hyaluronic acid (HA) is a key component of the extracellular matrix known for absorbing water, swell...
Microcurrent therapy (MCT) involves the application of sub-sensory electric current and can promote ...
Limited autologous vascular graft availability and poor patency rates of synthetic grafts for small-...
textThis study investigated the effect of bone marrow derived mesenchymal stem cells (MSCs) in a PEG...
PhD ThesisOsteoarthritis (OA) is a common degenerative disease of articular joints characterised by ...
thesisElevated circulating fatty acids can cause oxidative stress and impair endothelial function, l...
The local release of complexed siRNA from biomaterials enables targeted therapy of specific cells an...
Abstract 1) A variety of stem/progenitor populations have been isolated from human dental tissue ove...
Low back pain affects nearly 85% of the population of the United States, and is associated with a hu...
Background - In the recent wars, 77% of all British casualties received extremity injuries. The crit...