A practical drug discovery project for third-year undergraduates is described. No previous knowledge of medicinal chemistry is assumed. Initial lecture-workshops cover the basic principles; then students are asked to improve the profile of a weakly potent, poorly soluble PI3K inhibitor (1). Compound array design, molecular modelling and screening data analysis are followed by laboratory work in which each student, as part of a team, attempts to synthesise at least two target compounds. The project benefits from significant industrial support, including lectures, student mentoring and consumables. The aim is to make the learning experience as close as possible to real-life industrial situations. Forty-eight target compounds have been p...
A third-year specialist course in drug design and delivery focused on a single laboratory goal for a...
Drug discovery is a constantly developing and expanding area of research. Developed to provide a com...
An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as p...
Teaser'You make the compounds you design': this article describes a new way for chemistry ...
Highlights •A hybrid undergraduate laboratory course combines laboratory skills and exposure to rese...
Globalization has driven new paradigms for drug discovery and development. Activities previously car...
A four step process of high quality modelling of existing data, deconstruction, identification of re...
We have implemented at the University of Málaga (Spain) a new course-based undergraduate research ex...
This report focusses on the concept of lead-oriented synthesis in an attempt to synthesise diverse s...
During the redesign of the BSc degree structure at UNSW in 1998-1999, we set out to develop some thi...
The complexities of modern drug discovery-an interdisciplinary process that often takes years and co...
We have successfully implemented the concept of Distributed Drug Discovery (D3) in the search for CN...
The availability of suitable diverse fragment- and lead-oriented screening compounds is key for the ...
Within university chemistry departments, organic chemists are formulating reaction pathways which wi...
This project focused on the synthesis of a range 1,4-disubstituted-1,2,3-triazoles with the ap...
A third-year specialist course in drug design and delivery focused on a single laboratory goal for a...
Drug discovery is a constantly developing and expanding area of research. Developed to provide a com...
An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as p...
Teaser'You make the compounds you design': this article describes a new way for chemistry ...
Highlights •A hybrid undergraduate laboratory course combines laboratory skills and exposure to rese...
Globalization has driven new paradigms for drug discovery and development. Activities previously car...
A four step process of high quality modelling of existing data, deconstruction, identification of re...
We have implemented at the University of Málaga (Spain) a new course-based undergraduate research ex...
This report focusses on the concept of lead-oriented synthesis in an attempt to synthesise diverse s...
During the redesign of the BSc degree structure at UNSW in 1998-1999, we set out to develop some thi...
The complexities of modern drug discovery-an interdisciplinary process that often takes years and co...
We have successfully implemented the concept of Distributed Drug Discovery (D3) in the search for CN...
The availability of suitable diverse fragment- and lead-oriented screening compounds is key for the ...
Within university chemistry departments, organic chemists are formulating reaction pathways which wi...
This project focused on the synthesis of a range 1,4-disubstituted-1,2,3-triazoles with the ap...
A third-year specialist course in drug design and delivery focused on a single laboratory goal for a...
Drug discovery is a constantly developing and expanding area of research. Developed to provide a com...
An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as p...