Hereditary cystic kidney diseases: autosomal dominant and autosomal recessive polycystic kidney disease (ADPKD and ARPKD)

Cystic kidney diseases are among the most important causes of end-stage renal disease in both children and adults. While the more frequent autosomal dominant polycystic kidney disease (ADPKD) typically becomes clinically manifest in adulthood, the rare autosomal recessive polycystic kidney disease (ARPKD) is an often severe disorder of early childhood. The growing insight into the underlying genetic changes and molecular disease mechanisms has recently led to the development of the first therapeutic options