Multiple primary malignant tumours (MPMT) are an indicator of potential inherited cancer susceptibility and occur at appreciable frequency among unselected cancer patients and, particularly, among referrals to cancer genetics services. However, there is little information on the clinical genetic evaluation of cohorts of MPMT patients representing a variety of tumour types. A referral based case series was ascertained and is described. Service-based molecular genetic testing had demonstrated a pathogenic germline variant in a cancer predisposition gene in less than a quarter of referrals. To assess for evidence of unidentified variants in those who tested negative, comparisons were made with those who tested positive, revealing considerable ...
Association between histones and DNA is crucial for many cellular functions such as gene transcripti...
Background: Cancer represents a significant source of morbidity and mortality in people living with ...
The Nance-Horan syndrome gene (NHS) plays a role in lens, eye and brain development. To date, the fu...
dissertationAnthropologists provide a valuable service to the medico-legal community. They are taske...
DNA damage elicits a complex and detailed repair response involving multiple pathways. Defects in th...
The primary aims of this study were to examine acquired genetic and epigenetic changes that occur in...
Human cytomegalovirus (HCMV) is a highly species-specific, common human pathogen. While a large majo...
Helicobacter pylori is a gram-negative bacteria that is responsible for causing chronic gastritis, u...
Effective prediction of diagnosis and prognosis in cancer is an important step for selection of a su...
The expected growth of the older adult population in the United States over the next several decades...
thesisChromosomes are constantly under threat from DNA damaging agents. The cellular response to DNA...
Cancer remains a major public health challenge. The high mortality rate associated with cancer is du...
Alcohol use disorder (AUD) is the fourth leading cause of preventable death in the United States, an...
Thesis advisor: Charles S. HoffmanGlucose detection in yeast occurs via a cAMP signaling pathway tha...
MDM2, the human homologue of the Mouse Double Minute 2 gene product, has been shown to be over-expr...
Association between histones and DNA is crucial for many cellular functions such as gene transcripti...
Background: Cancer represents a significant source of morbidity and mortality in people living with ...
The Nance-Horan syndrome gene (NHS) plays a role in lens, eye and brain development. To date, the fu...
dissertationAnthropologists provide a valuable service to the medico-legal community. They are taske...
DNA damage elicits a complex and detailed repair response involving multiple pathways. Defects in th...
The primary aims of this study were to examine acquired genetic and epigenetic changes that occur in...
Human cytomegalovirus (HCMV) is a highly species-specific, common human pathogen. While a large majo...
Helicobacter pylori is a gram-negative bacteria that is responsible for causing chronic gastritis, u...
Effective prediction of diagnosis and prognosis in cancer is an important step for selection of a su...
The expected growth of the older adult population in the United States over the next several decades...
thesisChromosomes are constantly under threat from DNA damaging agents. The cellular response to DNA...
Cancer remains a major public health challenge. The high mortality rate associated with cancer is du...
Alcohol use disorder (AUD) is the fourth leading cause of preventable death in the United States, an...
Thesis advisor: Charles S. HoffmanGlucose detection in yeast occurs via a cAMP signaling pathway tha...
MDM2, the human homologue of the Mouse Double Minute 2 gene product, has been shown to be over-expr...
Association between histones and DNA is crucial for many cellular functions such as gene transcripti...
Background: Cancer represents a significant source of morbidity and mortality in people living with ...
The Nance-Horan syndrome gene (NHS) plays a role in lens, eye and brain development. To date, the fu...