Uremic toxins classification

Centrul Dializă şi Transplant Renal IMSP Spitalul Clinic Republican, Catedra Urologie şi Nefrologie Chirurgicală USMF “N.Testemiţanu”, Al V-lea Congres de Urologie, Dializă şi Transplant Renal din Republica Moldova cu participare internaţională (1-13 iunie 2011)Summary. The uremic syndrome is attributed to the progressive retention of a large number of compounds, which under normal conditions are excreted by the healthy kidneys. Uremic retention is a complex problem that concerns many more solutes than the current markers of urea and creatinine alone. The presented list provides a basis for systematic analytic approache of uremic toxins. Concentrations of retention solutes in uremia vary over a broad range, from nanograms per liter to grams per liter. Low concentrations are found especially for the middle molecules. A substantial number of molecules are protein bound and/or middle molecules