Biochemical changes in bone and joints pathology in patients with chronic kidney disease stage V under dialysis

Catedra Boli Interne Nr 5, Departamentul Nefrologie şi Reumatologie, USMF ”N.Testemiţanu”, Secţia Hemodializă, IMSP CNŞPMU, Al V-lea Congres de Urologie, Dializă şi Transplant Renal din Republica Moldova cu participare internaţională (1-13 iunie 2011)Summary. The objective of the study was to determine the biochemical changes in mineral metabolism and bone disease in hemodialysis (HD) patients and determine risk factors that may influence their disorder, as well as the clinical practices for bone disease control in relation to the laboratory targets recommended in the National kidney Foundation Dialysis Outcomes Quality Initiative (kDOQI) guidelines. The mean values for calcium were 2,28 ± 0.37 mmol/l, phosphorus 2.13 ± 0.37 mmol/l, intact PTH (iPTH) 386 ± 365 pg/ml, Ca X P 4,91 ± 1,1 mmol2 /l2, total alkalin phosphathase (tAP) 292,39±174,9 UI. Hypocalcemia (2,4mmol/l). Hyperphosphoremia (>1,8mmol/l) was present in 52.4% of patients. Ca X P was 300 pg/ml), being severe in 12% (>600 pg/ml); 30,4% of patients presented iPTH