Alkylating agents are widespread in the environment and also occur endogenously. They can be cytotoxic or mutagenic to the cells introducing alkylated bases to DNA or RNA. All organisms have evolved multiple DNA repair mechanisms to counteract the effects of DNA alkylation: the most cytotoxic lesion, N3-methyladenine (3meA), is excised by AlkA glycosylase initiating base excision repair (BER); toxic N1-methyladenine (1meA) and N3-methylcytosine (3meC), induced in DNA and RNA, are removed by AlkB dioxygenase; and mutagenic and cytotoxic O6-methylguanine (O6meG) is repaired by Ada methyltransferase. In Escherichia coli, Ada response involves the expression of four genes, ada, alkA, alkB, and aidB, encoding respective proteins Ada, AlkA, AlkB,...
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms h...
Alkylation damage to DNA occurs when cells encounter alkylating agents in the environment or when ce...
AbstractThe identification of cellular responses to damage can promote mechanistic insight into stre...
Environmental and endogenous alkylating agents generate cytotoxic and mutagenic lesions in DNA. Expo...
In 1977 a novel, inducible and error free DNA repair system in Escherichia coli came to light. It pr...
<div><p>Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induc...
: Several alkylating agents that either occur in the environment or are self-produced can cause DNA...
: Several alkylating agents that either occur in the environment or are self-produced can cause DNA...
: Several alkylating agents that either occur in the environment or are self-produced can cause DNA...
AbstractRecent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, w...
The activated Ada protein triggers expression of DNA repair genes in Escherichia coli in response to...
Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of ...
When Escherichia coli cells are exposed to low, non-lethal doses of simple alkylating agents, such a...
The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direc...
In Escherichia coli the alkylating agent methyl methanesulfonate (MMS) induces defense systems (adap...
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms h...
Alkylation damage to DNA occurs when cells encounter alkylating agents in the environment or when ce...
AbstractThe identification of cellular responses to damage can promote mechanistic insight into stre...
Environmental and endogenous alkylating agents generate cytotoxic and mutagenic lesions in DNA. Expo...
In 1977 a novel, inducible and error free DNA repair system in Escherichia coli came to light. It pr...
<div><p>Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induc...
: Several alkylating agents that either occur in the environment or are self-produced can cause DNA...
: Several alkylating agents that either occur in the environment or are self-produced can cause DNA...
: Several alkylating agents that either occur in the environment or are self-produced can cause DNA...
AbstractRecent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, w...
The activated Ada protein triggers expression of DNA repair genes in Escherichia coli in response to...
Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of ...
When Escherichia coli cells are exposed to low, non-lethal doses of simple alkylating agents, such a...
The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direc...
In Escherichia coli the alkylating agent methyl methanesulfonate (MMS) induces defense systems (adap...
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms h...
Alkylation damage to DNA occurs when cells encounter alkylating agents in the environment or when ce...
AbstractThe identification of cellular responses to damage can promote mechanistic insight into stre...