CHALCONES: THE PROMISING COMPOUNDS TO PROVIDE NEW WAYS FOR CANCER TREATMENT

Chalcones (1,3-diphenylpropen-1-ones), a biosynthetic product of the shikimate pathway, belonging to flavanoid family are precursors of open chain flavonoids and isoflavonoids, which are abundant in edible plants. They have a wide variety of cytoprotective and modulatory functions, which may have therapeutic potential for multiple diseases, especially as antitumor drugs. Several natural and synthetic chalcones and their derivatives appear as promising anticancer activities. Their chemical structure evaluation will be critical to assess their therapeutic utility. Those for which the mechanism of action is well defined can serve as lead compounds for the design of new, more promising molecules. The present review highlights the recently natural synthesized chalcones and their derivatives possessing important pharmacological activities as anticancer and how the mechanism pathways of these compounds in inhibiting cancer cells