The Impacts of Some Sedative Drugs on alpha -Glycosidase, Acetylcholinesterase and Butyrylcholinesterase Enzymes-potential Drugs for Some Metabolic Diseases

Background: The present paper focuses on the in vitro inhibition of some sedative drugs such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly) enzymes. Methods: These drugs were tested in diverse concentrations, which showed positive effects in vitro AChE, BChE, and alpha-Gly activities. Ki values were 20.14, 94.93, 636.78, 416.42, and 953.75 mu M for AChE, 17.52, 32.03, 88.02, 93.48, and 91.84 mu M for BChE, and 10.87, 156.68, 48.21, 37.88, 151.01 mu M for a-glycosidase, respectively. Results: An enhancing number of experiential observations show potentially harmful effects of sedative drugs on the extension of brain Conclusion: Midazolam exhibited effective inhibitory activity compared with the other drugs for these enzymes