Association between Platelet Counts before and during Pharmacological Therapy for Patent Ductus Arteriosus and Treatment Failure in Preterm Infants
- Sallmon, Hannes
- Weber, Sven C.
- Dirks, Juliane
- Schiffer, Tamara
- Klippstein, Tamara
- Stein, Anja
- Felderhoff-Müser, Ursula
- Metze, Boris
- Hansmann, Georg
- Bührer, Christoph
- Cremer, Malte
- Koehne, Petra
DOIAbstract
Background The role of platelets for mediating closure of the ductus arteriosus in human preterm infants is controversial. Especially, the effect of low platelet counts on pharmacological treatment failure is still unclear. Methods In this retrospective study of 471 preterm infants [<1,500 g birth weight (BW)], who were treated for a patent ductus arteriosus (PDA) with indomethacin or ibuprofen, we investigated whether platelet counts before or during pharmacological treatment had an impact on the successful closure of a hemodynamically significant PDA. The effects of other factors, such as sepsis, preeclampsia, gestational age, BW, and gender, were also evaluated. Results Platelet counts before initiation of pharmacological PD...
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