Numerical investigation of muco-ciliary transport

The human airways are protected from inhaled external substances by an extremely thin layer called airway surface liquid. This film of liquid captures most of the inhaled toxic particles and is constantly propelled back out of the airway by a dense mat of beating hair-like structures, thus cleansing the airways of inhaled pathogens. It is vital to better understand this clearance process under diseased conditions and to predict the fate of therapeutic drug particles after deposition. An advanced numerical model is developed to investigate these objectives, given that the complex nature of lung clearance limits the ability to conduct experiments