Tissue-engineered fibroin scaffolds for ocular tissue reconstruction
- Bray, Laura J.
- George, Karina A.
- Hutmacher, Dietmar
- Chirila, Traian V.
- Harkin, Damien G.
DOIAbstract
The silk protein fibroin (Bombyx mori) provides a potential substrate for use in ocular tissue reconstruction. We have previously demonstrated that transparent membranes produced from fibroin support cultivation of human limbal epithelial (HLE) cells (Tissue Eng A. 14(2008)1203-11). We extend this body of work to studies of limbal mesenchymal stromal cell (L-MSC) growth on fibroin. Also, we investigate the ability to produce a fibroin dual-layer scaffold with an upper HLE layer and lower L-MSC layer..
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