Similarity Check Antihypercholesterol Activity of Costus Speciosus Water Extract

Introduction: Hypercholesterolemia is one of the causes of cardiovascular disease. Costus speciosus (CS) is known empirically as an antihypercholesterol remedy. Material and Method: This study was conducted to determine the effect of water extract of CS on cholesterol blood serum level of rat induced-propylthiouracil (PTU). The antihypercholesterol activity performed on male Wistar rats which induced 0.01% PTU (mixed in drinking water, 14 day-induction) was followed by the administration of CS for 14 days. The animals were randomly divided into seven groups: Solvent control (carboxylmethylcellulose 0.5% w/v in water), positive control (simvastatin at dose 7.2 mg/kg BW), negative control (water), CS extract 50, 100, and 200 mg/kg, and normal control. The cholesterol levels were measured at day 0th, 14th, and 28th. Result and Conclusion: Results showed that administration of CS extract 200 mg/kg can reduce the total serum cholesterol equal to simvastatin 7.2 mg/kg