Cardiometabolic Traits, Sepsis, and Severe COVID-19: A Mendelian Randomization Investigation.
- Ponsford, Mark J
- Gkatzionis, Apostolos
- Walker, Venexia M
- Grant, Andrew J
- Wootton, Robyn E
- Moore, Luke SP
- Fatumo, Segun
- Mason, Amy
- Zuber, Verena
- Willer, Cristen
- Rasheed, Humaira
- Brumpton, Ben
- Hveem, Kristian
- Kristian Damås, Jan
- Davies, Neil
- Åsvold, Bjørn Olav
- Solligård, Erik
- Jones, Simon
- Burgess, Stephen
- Rogne, Tormod
- Gill, Dipender
DOIAbstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Many patients with severe COVID-19 develop sepsis. Cardiometabolic traits have been associated with increased risk of severe COVID-19 and sepsis, however it is difficult to infer causal effects from observational studies due to the possibility that any identified associations may be attributable to confounding
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