Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system and TLRs provide important pattern recognition receptors initiating the cytokine storm by extensive cross-talk. We hypothesized that double blockade of complement C5 and the TLR coreceptor CD14 could improve survival of experimental polymicrobial sepsis. Mice undergoing cecal ligation and puncture (CLP)–induced sepsis were treated with neutralizing anti-CD14 Ab biG 53, complement C5 inhibitor coversin (Ornithodoros moubata C inhibitor), or a combination thereof. The inflammatory study (24-h observation) revealed statistically significant increases in 22 of 24 measured plasma biomarkers ...
Complement 5a (C5a) and Interleukin-17 (IL-17) are two important inflammatory mediators in sepsis. H...
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154678/1/fsb2fj08110595.pd
Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective ther...
Introduction: Sepsis is an exaggerated and dysfunctional immune response to infection. Activation of...
The host is protected by pattern recognition systems, including complement and TLRs, which are close...
Complement and the TLR family constitute two important branches of innate immunity. We previously sh...
Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of ...
Background Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, m...
Innate immune functions are known to be compromised during sepsis, often with lethal consequences. T...
• Introduction - Models of sepsis - Evidence for complement activation in sepsis - Protectiv...
Combined inhibition of complement and CD14 is known to attenuate bacterial-induced inflammation, but...
Objective: Binding of bacterial cell wall components to CD14 and co-receptors on myeloid cells resul...
In this mini review, we describe the molecular mechanisms in polymicrobial sepsis that lead to a ser...
<p>Mice were pre-treated with individual or combined anti-TLR2 or anti-TLR4 antibodies (45 minutes b...
Background: Sepsis is a dysregulated host response to infection. The aim of this study was to invest...
Complement 5a (C5a) and Interleukin-17 (IL-17) are two important inflammatory mediators in sepsis. H...
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154678/1/fsb2fj08110595.pd
Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective ther...
Introduction: Sepsis is an exaggerated and dysfunctional immune response to infection. Activation of...
The host is protected by pattern recognition systems, including complement and TLRs, which are close...
Complement and the TLR family constitute two important branches of innate immunity. We previously sh...
Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of ...
Background Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, m...
Innate immune functions are known to be compromised during sepsis, often with lethal consequences. T...
• Introduction - Models of sepsis - Evidence for complement activation in sepsis - Protectiv...
Combined inhibition of complement and CD14 is known to attenuate bacterial-induced inflammation, but...
Objective: Binding of bacterial cell wall components to CD14 and co-receptors on myeloid cells resul...
In this mini review, we describe the molecular mechanisms in polymicrobial sepsis that lead to a ser...
<p>Mice were pre-treated with individual or combined anti-TLR2 or anti-TLR4 antibodies (45 minutes b...
Background: Sepsis is a dysregulated host response to infection. The aim of this study was to invest...
Complement 5a (C5a) and Interleukin-17 (IL-17) are two important inflammatory mediators in sepsis. H...
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154678/1/fsb2fj08110595.pd
Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective ther...