Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications
- Kalot, Ghadir
- Godard, Amélie
- Busser, Benoît
- Pliquett, Jacques
- Broekgaarden, Mans
- Motto-Ros, Vincent
- Wegner, Karl David
- Resch-Genger, Ute
- Köster, Ulli
- Denat, Franck
- Coll, Jean-Luc
- Bodio, Ewen
- Goze, Christine
- Sancey, Lucie
DOIAbstract
International audienceBoron neutron capture therapy (BNCT) is a radiotherapeutic modality based on the nuclear capture of slow neutrons by stable 10 B atoms followed by charged particle emission that inducing extensive damage on a very localized level (<10 µm). To be efficient, a sufficient amount of 10 B should accumulate in the tumor area while being almost cleared from the normal surroundings. A water-soluble aza-boron-dipyrromethene dyes (BODIPY) fluorophore was reported to strongly accumulate in the tumor area with high and BNCT compatible Tumor/Healthy Tissue ratios. The clinically used 10 B-BSH (sodium borocaptate) was coupled to the water-soluble aza-BODIPY platform for enhanced 10 B-BSH tumor vectorization. We demonstrated a strong...
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