Topiramat (TPM) je protiepileptična učinkovina 2. generacije, namenjena za zdravljenje epilepsije samostojno ali v kombinaciji z drugimi zdravili. Uporablja se tudi za zdravljenje migrene pri odraslih ter napadih povezanih z Lennox – Gastautovim sindrom pri otrocih. Presnova TPM, kljub njegovi pogosti uporabi, še ni čisto razjasnjena. V ta namen je bila predhodno razvita zelo občutljiva (meja določitve presnovkov do 0,001 mg/L) in validirana analizna metoda na sistemu LC-MS/MS. Ta metoda nam je omogočila analizo realnih plazemskih vzorcev 66 bolnikov na rednem zdravljenju epilepsije s TPM ter ovrednotenje koncentracij TPM in njegovih petih presnovkov. Metodo smo pred izvedbo analiz preverili z ustreznimi vzorci ter jo prilagodili in nadgrad...
Objective: The objective of this research was to develop and validate a simple, sensitive and specif...
Cilj istraživanja: Utvrditi koliko često se određivala koncentracija antiepileptika nove generacije ...
Topiramate (2,3:4,5-bis-O −(1-methylethylidene)-D-fructopyranose sulfamate) is one of the most...
Topiramat (TPM) je protiepileptična učinkovina 2. generacije, namenjena za zdravljenje epilepsije sa...
The LC-MS/MS method for determination of the anti-epileptic drug topiramate (TPM) in human plasma wa...
A novel liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for quant...
Cilj doktorske disertacije je bio da se istraže, otkriju i kvantitativno izraze uticaji faktorakoji ...
Epilepsy is one of the most wide spread and serious paroxysmal disorders as well as 30% cases of res...
SummaryObjectiveTo investigate the relevance of serum topiramate (TPM) levels (SL) monitoring in the...
International audienceTherapeutic drug monitoring of antiepileptic drugs is widely practiced to achi...
Bu çalışmada, topiramat (TPM) tedavisinin hipokampüsde çinko iyonu translokasyonu üzerine olan akut ...
Topiramate (TPM) is a new antiepiletic drug with efficacy in several types of seizures. Therapeutic ...
AbstractAntiepileptic drugs are the first choice for epilepsy treatment. Monitoring antiepileptic dr...
The objective of the study was to develop population pharmacokinetic model of topiramate (TPM) using...
Uvod: Karbamazepin je antiepileptik s uskim terapijskim rasponom pa je nužno njegovo terapijsko prać...
Objective: The objective of this research was to develop and validate a simple, sensitive and specif...
Cilj istraživanja: Utvrditi koliko često se određivala koncentracija antiepileptika nove generacije ...
Topiramate (2,3:4,5-bis-O −(1-methylethylidene)-D-fructopyranose sulfamate) is one of the most...
Topiramat (TPM) je protiepileptična učinkovina 2. generacije, namenjena za zdravljenje epilepsije sa...
The LC-MS/MS method for determination of the anti-epileptic drug topiramate (TPM) in human plasma wa...
A novel liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for quant...
Cilj doktorske disertacije je bio da se istraže, otkriju i kvantitativno izraze uticaji faktorakoji ...
Epilepsy is one of the most wide spread and serious paroxysmal disorders as well as 30% cases of res...
SummaryObjectiveTo investigate the relevance of serum topiramate (TPM) levels (SL) monitoring in the...
International audienceTherapeutic drug monitoring of antiepileptic drugs is widely practiced to achi...
Bu çalışmada, topiramat (TPM) tedavisinin hipokampüsde çinko iyonu translokasyonu üzerine olan akut ...
Topiramate (TPM) is a new antiepiletic drug with efficacy in several types of seizures. Therapeutic ...
AbstractAntiepileptic drugs are the first choice for epilepsy treatment. Monitoring antiepileptic dr...
The objective of the study was to develop population pharmacokinetic model of topiramate (TPM) using...
Uvod: Karbamazepin je antiepileptik s uskim terapijskim rasponom pa je nužno njegovo terapijsko prać...
Objective: The objective of this research was to develop and validate a simple, sensitive and specif...
Cilj istraživanja: Utvrditi koliko često se određivala koncentracija antiepileptika nove generacije ...
Topiramate (2,3:4,5-bis-O −(1-methylethylidene)-D-fructopyranose sulfamate) is one of the most...