The Association Between Cytomegalovirus Infection and Cardiac Allograft Vasculopathy in the Era of Antiviral Valganciclovir Prophylaxis
- Klimczak-Tomaniak, D.
- Roest, S. (Stefan)
- Brugts, J.J. (Jasper)
- Caliskan, K.C. (Kadir)
- Kardys, I. (Isabella)
- Zijlstra, F. (Felix)
- Constantinescu, A.A. (Alina)
- Voermans, J. (Jolanda)
- Kampen, J.J.A. (Jeroen) van
- Manintveld, O.C. (Olivier)
DOIAbstract
Background. Previous studies on the association between cytomegalovirus (CMV) infection and cardiac allograft vasculopathy (CAV) were conducted on patients transplanted in the prevalganciclovir prophylaxis era. The aim of our study is to evaluate this relation in heart transplantation (HTx) recipients treated according to current prophylactic and immunosuppressive regimens. Methods. This single-center retrospective study included all consecutive adult patients that underwent HTx between January 1, 2000, and May 31, 2018. Clinically relevant CMV infection was defined as either plasma CMV DNAemia ≥ 1000 IU/mL with/without clinical symptoms or <1000 IU/mL with symptoms. The primary endpoint was first manifestation of CAV diagnosed by coron...
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