Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
- An, Jiyuan
- Gharahkhani, Puya
- Law, Matthew H.
- Ong, Jue-Sheng
- Han, Xikun
- Olsen, Catherine M.
- Neale, Rachel E.
- Lai, John
- Vaughan, Tom L.
- Gockel, Ines
- Thieme, René
- Böhmer, Anne C.
- Jankowski, Janusz
- Fitzgerald, Rebecca C.
- Schumacher, Johannes
- Palles, Claire
- Whiteman, David C.
- MacGregor, Stuart
- Gammon, Marilie D.
- Corley, Douglas A.
- Shaheen, Nicholas J.
- Bird, Nigel C.
- Hardie, Laura J.
- Murray, Liam J.
- Reid, Brian J.
- Chow, Wong-Ho
- Risch, Harvey A.
- Ye, Weimin
- Liu, Geoffrey
- Romero, Yvonne
- Bernstein, Leslie
- Wu, Anna H.
- Agee, M.
- Alipanahi, B.
- Auton, A.
- Bell, R. K.
- Bryc, K.
- Elson, S. L.
- Fontanillas, P.
- Furlotte, N. A.
- Hinds, D. A.
- Huber, K. E.
- Kleinman, A.
- Litterman, N. K.
- McIntyre, M. H.
- Mountain, J. L.
- Noblin, E. S.
- Northover, C. A. M.
- Pitts, S. J.
- Sathirapongsasuti, J. Fah
- Sazonova, O. V.
- Shelton, J. F.
- Shringarpure, S.
- Tian, C.
- Tung, J. Y.
- Vacic, V.
- Wilson, C. H.
DOIAbstract
Funder: The Swedish Esophageal Cancer Study was funded by grants (R01 CA57947-03) from the National Cancer Institute he California Tobacco Related Research Program (3RT-0122; and; 10RT-0251) Marit Peterson Fund for Melanoma Research. CIDR is supported by contract HHSN268200782096CAbstract: Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large GERD GWAS meta-analysis (80,265 cases, 305,011 controls), identifying 25 independent genome-wide significant loci for GERD. Several of the implicated genes are existing or putative drug targets. Loci discovery is greatest with a bro...
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