Objective Recently, tumours with microsatellite instability (MSI)/defective DNA mismatch repair (dMMR) have gained considerable interest due to the success of immunotherapy in this molecular setting. Here, we aim to clarify clinical-pathological and/or molecular features of this tumour subgroup through a systematic review coupled with a comparative analysis with existing databases, also providing indications for a correct approach to the clinical identification of MSI/dMMR pancreatic ductal adenocarcinoma (PDAC). Design PubMed, SCOPUS and Embase were searched for studies reporting data on MSI/dMMR in PDAC up to 30 November 2019. Histological and molecular data of MSI/dMMR PDAC were compared with non-MSI/dMMR PDAC and with PDAC reference co...
Background: Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease, with very little imp...
Pancreatic ductal adenocarcinoma (PDAC) is a major health problem in France and around the world. PD...
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal ad...
Objective: Recently, tumours with microsatellite instability (MSI)/defective DNA mismatch repair (dM...
Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small ...
Objectives: Molecular alterations inaboit 1%of Pancreatic Ductal AdenoCarcinoma(PDAC) includes Micro...
Background: Molecular alterations described in Pancreatic Ductal AdenoCarcinoma (PDAC) include Micro...
Pancreatic ductal adenocarcinoma (PDAC) is a biologically aggressive malignancy showing a remarkable...
Background: Pancreatic Ductal AdenoCarcinoma (PDAC) may present MicroSatellite Instability (MSI), ph...
Objectives: Pancreatic Ductal AdenoCarcinoma (PDAC) presents in about 1% of cases MicroSatellite Ins...
L’adénocarcinome canalaire du pancréas (ACP) est un problème majeur de santé publique. L’ACP se déve...
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK ...
Background and Aims: Pancreatic cancer risk is increased in Lynch syndrome (LS) patients with mismat...
Despite the efforts made in the management of PDAC, the 5-year relative survival rate of pancreatic ...
Pancreatic cancer risk is increased in Lynch syndrome (LS) patients with mismatch repair gene defect...
Background: Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease, with very little imp...
Pancreatic ductal adenocarcinoma (PDAC) is a major health problem in France and around the world. PD...
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal ad...
Objective: Recently, tumours with microsatellite instability (MSI)/defective DNA mismatch repair (dM...
Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small ...
Objectives: Molecular alterations inaboit 1%of Pancreatic Ductal AdenoCarcinoma(PDAC) includes Micro...
Background: Molecular alterations described in Pancreatic Ductal AdenoCarcinoma (PDAC) include Micro...
Pancreatic ductal adenocarcinoma (PDAC) is a biologically aggressive malignancy showing a remarkable...
Background: Pancreatic Ductal AdenoCarcinoma (PDAC) may present MicroSatellite Instability (MSI), ph...
Objectives: Pancreatic Ductal AdenoCarcinoma (PDAC) presents in about 1% of cases MicroSatellite Ins...
L’adénocarcinome canalaire du pancréas (ACP) est un problème majeur de santé publique. L’ACP se déve...
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK ...
Background and Aims: Pancreatic cancer risk is increased in Lynch syndrome (LS) patients with mismat...
Despite the efforts made in the management of PDAC, the 5-year relative survival rate of pancreatic ...
Pancreatic cancer risk is increased in Lynch syndrome (LS) patients with mismatch repair gene defect...
Background: Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease, with very little imp...
Pancreatic ductal adenocarcinoma (PDAC) is a major health problem in France and around the world. PD...
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal ad...