The strong coupling dynamics of Quantum Field Theories with gauge symmetries constitutes a profound problem in Theoretical Physics. Supersymmetric theories offer rare instances where this elusive problem is tractable and can be a valuable source of information and intuition. One of the most powerful approaches available for this purpose is supersymmetric localization. In this thesis, we employ this technique to study many facets of supersymmetric theories. After a brief theoretical introduction to the basic concepts that make an appearance in this thesis, we begin with a localization computation for supersymmetric gauges theories on spheres of variable dimension, with eight and four supersymmetries, proving an earlier conjecture. We also an...