Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology

The aim of this research is to know the effect of short-term bitter melon (Momordica Charantia L.) fruit concentrated infusions therapy on the histology of alloxan-induced rat kidney glomerulus. Renal glomerular histology was observed using Hematoxylin-Eosin (HE) test. A therapeutic dose of bitter melon fruit concentrated therapy used was 0.15 mL/200 g BW; 0.30 mL/200 g BW; 0.45 mL/200 g BW; 0.60 mL/200 g BW; 0.80 mL/200 g BW and 1 mL/200 g BW. The results showed that the bitter melon fruit concentrated infusions therapy on alloxan-induced DM rats was able to decrease the Blood Glucose Levels (BGL) of the treated rats in varying degrees. The therapy also successfully repairs the damage kidney glomerulus cells of all rats treated with an average bowman's space improvement of 110% of healthy rat's kidney glomerulus cells. It appears that the mechanism of the bitter melon active substance in reducing the BGL occurs through a different path to its mechanism in repairing damaged glomerulus cells