The relationship between epicardial adipose tissue and biochemical parameters with contrast induced nephropathy in patients with percutaneous coronary intervention due to acute coronary syndrome

Aim: The aim of this study was to investigate whether there is a relationship between contrast induced nephropathy (CIN) and epicardial adipose tissue (EAT) in addition to biochemical parameters in patients undergoing coronary angiography (CAG) and percutaneous coronary intervention (PCI) due to acute coronary syndrome (ACS). Methods: Patients who underwent PCI due to ACS between 01/02/2017 and 01/09/2017 were also examined cross-sectional and retrospectively. A total of 302 patients were included in the study. A possible relationship between CIN with EAT, other echocardiographic parameters and biochemical parameters was evaluated by statistical analysis. Results: 61 of the patients developed CIN (age: 67.8 ± 12.8 years) and 241 of them did not develop CIN (age: 61.5 ± 10.9). EAT, age, hypertension, aortic sclerosis, HbA1c, uric acid, fibrinogen, DM, insulin use, smoking, Mehran score, mitral annuler calcification and creatinine levels on admisson were found to be related to CIN. Aortic sclerosis, uric acid and HbA1c were independent predictor of the development of CIN. Conclusions: In patients who underwent PCI due to ACS, an increase in the amount of EAT was associated with the risk of developing CIN. Aortic sclerosis, uric acid and HbA1c were independent risk factors for CIN. Keywords: Acute coronary syndrome, epicardial adipose tissue, contrast induced nephropath