In the diabetic state, there is an enhanced oxidative stress due to excessive production of reactive oxygen compounds and decreased bioavailability of nitric oxide. Antioxidant treatment has been used to prevent oxidative damage in diabetes. The objective of the present study was to explore the effects of atorvastatin (AT) and melatonin (MLT) on oxidative stress in diabetic rat pancreas. We also assessed nitric oxide synthase (NOS) activity and apoptosis. Diabetes was induced by an alkylating agent steptozotocin (STZ, 55 mg/kg, IP). Six weeks later rats were divided into five groups: STZ-induced diabetic group received atorvastatin (STZ+AT), STZ-induced diabetic group received melatonin (STZ+MLT) and STZ-induced diabetic group received ator...
Oxidative stress-mediated damage to liver tissue underlies the pathological alterations in liver...
International audienceIn this work we have studied the effects of pharmacological concentrations of ...
High blood glucose levels induce metabolic disorders that initiate a sequence of events including re...
In the diabetic state, there is an enhanced oxidative stress due to excessive production of reactive...
Oxidative stress plays an important role in the development of complications in diabetes mellitus. A...
Copyright © 2012 Tuğba Gürpınar et al. This is an open access article distributed under the Creati...
Enhanced oxidative stress due to diabetes is accepted to lead to endothelial dysfunction, and this i...
This study investigated the possible protective effects of melatonin as an antioxidant against strep...
The aim of this study was to investigate the effects of melatonin as an antioxidant, on prevention a...
Vascular dysfunction is thought to play a major role in the development of diabetic cardiovascular d...
Evidence has long been existed regarding the relationship between oxidative stress and diabetes. The...
Purpose: Melatonin (N-acetyl-5-methoxy-tryptamine) is synthesized mainly by the pineal gland and its...
Objective: The present study was designed to evaluate the effects of Atorvastatin (ATO) plus melaton...
One of the main goals of treatment of diabetes mellitus is to prevent its complications. Oxidative s...
This study investigated the antioxidant system response of male reproductive organs during early and...
Oxidative stress-mediated damage to liver tissue underlies the pathological alterations in liver...
International audienceIn this work we have studied the effects of pharmacological concentrations of ...
High blood glucose levels induce metabolic disorders that initiate a sequence of events including re...
In the diabetic state, there is an enhanced oxidative stress due to excessive production of reactive...
Oxidative stress plays an important role in the development of complications in diabetes mellitus. A...
Copyright © 2012 Tuğba Gürpınar et al. This is an open access article distributed under the Creati...
Enhanced oxidative stress due to diabetes is accepted to lead to endothelial dysfunction, and this i...
This study investigated the possible protective effects of melatonin as an antioxidant against strep...
The aim of this study was to investigate the effects of melatonin as an antioxidant, on prevention a...
Vascular dysfunction is thought to play a major role in the development of diabetic cardiovascular d...
Evidence has long been existed regarding the relationship between oxidative stress and diabetes. The...
Purpose: Melatonin (N-acetyl-5-methoxy-tryptamine) is synthesized mainly by the pineal gland and its...
Objective: The present study was designed to evaluate the effects of Atorvastatin (ATO) plus melaton...
One of the main goals of treatment of diabetes mellitus is to prevent its complications. Oxidative s...
This study investigated the antioxidant system response of male reproductive organs during early and...
Oxidative stress-mediated damage to liver tissue underlies the pathological alterations in liver...
International audienceIn this work we have studied the effects of pharmacological concentrations of ...
High blood glucose levels induce metabolic disorders that initiate a sequence of events including re...