Vita.This dissertation deals with both theoretical and practical aspects of integrated circuits (IC's) statistical design. It stresses and explains that the essential difference between IC statistical design and discrete circuit statistical design lies in basic statistical features of two types of circuits. The main emphasis of the research is placed on principles and practical solutions for performance variability minimization rather than manufacturing yield enhancement alone. A variability gradient formula applicable to a general IC statistical model is first developed, which leads to understanding of the nature of IC variability minimization problem, forms a theoretical basis for the possibility of IC variability minimization, and clarif...