International audienceWe investigated the impact of land-use change on the hydrology of different major Lao tributary watersheds of Mekong River. The region is the North of Laos centred on Luang Prabang and the watersheds are the Nam Khan, Nam Ou, Nam Suong, Nam Lik and Nam Ngum. An additional small agricultural catchment called Houay Pano close to the Nam Khan, is also considered. We used the lumped rainfall–-runoff conceptual models GR4J and GR2M, developed by Irstea in France, the Mekong River Commission hydro-meteorological database and the Japanese Aphrodite meteorological database. The objective was to detect in the hydrological regime of the watersheds an impact of de(re)forestation, processes known to have occurred since the 1980s, ...