In recent year, embedded systems architectures and applications have gained a lot of interest, especially the possibility to add on-bard intelligence has fostered research in several directions, including not only smart IoT and cyber physical systems, but also hot topics such as accelerating deep learning. This special issue contains four papers dealing with architectures and design methodologies to support embedded intelligence, but also providing best practices and software support. The paper “A Technologically Agnostic Framework for Cyber-Physical and IoT Processing-in-Memory-based Systems Simulation”, by Santos et al., aims to focus on Processing-In-Memory (PIM) as a solution for efficiently processing big data. In particular, this w...