Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage
- Fluckiger A.
- Daillere R.
- Sassi M.
- Sixt B. S.
- Liu P.
- Loos F.
- Richard C.
- Rabu C.
- Alou M. T.
- Goubet A. -G.
- Lemaitre F.
- Ferrere G.
- Derosa L.
- Duong C. P. M.
- Messaoudene M.
- Gagne A.
- Joubert P.
- De Sordi L.
- Debarbieux L.
- Simon S.
- Scarlata C. -M.
- Ayyoub M.
- Palermo B.
- Facciolo F.
- Boidot R.
- Wheeler R.
- Boneca I. G.
- Sztupinszki Z.
- Papp K.
- Csabai I.
- Pasolli E.
- Segata N.
- Lopez-Otin C.
- Szallasi Z.
- Andre F.
- Iebba V.
- Quiniou V.
- Klatzmann D.
- Boukhalil J.
- Khelaifia S.
- Raoult D.
- Albiges L.
- Escudier B.
- Eggermont A.
- Mami-Chouaib F.
- Nistico P.
- Ghiringhelli F.
- Routy B.
- Labarriere N.
- Cattoir V.
- Kroemer G.
- Zitvogel L.
DOIAbstract
Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2Kb-restricted CD8+ T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen...
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