Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion
- Kawasaki H.
- Takeuchi T.
- Ricciardiello F.
- Lombardi A.
- Biganzoli E.
- Fornili M.
- De Bortoli D.
- Mesolella M.
- Cossu A. M.
- Scrima M.
- Capasso R.
- Falco M.
- Motta G.
- Motta G.
- Testa D.
- De Luca S.
- Oliva F.
- Abate T.
- Mazzone S.
- Misso G.
- Caraglia M.
DOIAbstract
The need to identify molecular markers for early detection of laryngeal cancer prompted Kawasaki et al. to define a miRNA signature of tumor transformation and spreading. They showed the diagnostic and predictive potential of miR-133b and miR-449a, respectively, and demonstrated miR-449a-mediated suppression of the metastatic factors Notch1 and Notch2
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