IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome
- Yasin, Shima
- Fall, Ndate
- Brown, Rachel A
- Henderlight, Maggie
- Canna, Scott W
- Girard, Charlotte
- Gabay, Cem
- Grom, Alexei A
- Schulert, Grant S
DOIAbstract
Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS. We aimed to examine IL-18 levels in sJIA in relation to disease activity and history of MAS and other disease biomarkers namely S100 proteins and CXCL9
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