Gene-directed enzyme-prodrug therapy (GDEPT) employs tumour-tropic vectors including viruses (VDEPT) and bacteria (BDEPT) to deliver a genetically-encoded prodrug-converting enzyme to the tumour environment, thereby sensitising the tumour to a prodrug. Bacterial nitroreductases, which are able to activate a range of anti-cancer nitroaromatic prodrugs to genotoxic metabolites, are of particular interest for GDEPT. The bystander effect is crucial to the success of GDEPT. The bystander effect is a measure of how efficiently activated prodrug metabolites are transferred from gene-expressing cells to neighbouring tissues. This promotes more extensive tumour cell killing. The bystander effect has been quantified for multiple nitroaromatic prodru...
There is strong interest in developing novel targeted cancer therapies. It has been known for over a...
There is strong interest in developing novel targeted cancer therapies. It has been known for over a...
Specific tumour ablation through gene therapy holds great promise as an anti-cancer strategy. Gene t...
Gene-directed enzyme-prodrug therapy (GDEPT) employs tumour-tropic vectors including viruses (VDEPT)...
© 2018 Elsevier Inc. Gene-directed enzyme-prodrug therapy (GDEPT) employs tumour-tropic vectors incl...
© 2020 The Authors Bacterial-directed enzyme-prodrug therapy (BDEPT) uses tumour-tropic bacteria arm...
Nitroaromatic prodrugs are biologically inert compounds that are attractive candidates for anti-canc...
Nitroaromatic prodrugs are biologically inert compounds that are attractive candidates for anti-canc...
Cancer is an increasing global concern, with the number of people diagnosed growing rapidly each yea...
Cancer is an increasing global concern, with the number of people diagnosed growing rapidly each yea...
Cancer is an increasing global concern, with the number of people diagnosed growing rapidly each yea...
Bacterial nitroreductases are members of a diverse family of oxidoreductase enzymes that are capable...
Bacterial nitroreductases are members of a diverse family of oxidoreductase enzymes that are capable...
Bacterial nitroreductase enzymes, which exhibit the capacity to reduce a wide range of nitroaromatic...
Bacterial nitroreductase enzymes, which exhibit the capacity to reduce a wide range of nitroaromatic...
There is strong interest in developing novel targeted cancer therapies. It has been known for over a...
There is strong interest in developing novel targeted cancer therapies. It has been known for over a...
Specific tumour ablation through gene therapy holds great promise as an anti-cancer strategy. Gene t...
Gene-directed enzyme-prodrug therapy (GDEPT) employs tumour-tropic vectors including viruses (VDEPT)...
© 2018 Elsevier Inc. Gene-directed enzyme-prodrug therapy (GDEPT) employs tumour-tropic vectors incl...
© 2020 The Authors Bacterial-directed enzyme-prodrug therapy (BDEPT) uses tumour-tropic bacteria arm...
Nitroaromatic prodrugs are biologically inert compounds that are attractive candidates for anti-canc...
Nitroaromatic prodrugs are biologically inert compounds that are attractive candidates for anti-canc...
Cancer is an increasing global concern, with the number of people diagnosed growing rapidly each yea...
Cancer is an increasing global concern, with the number of people diagnosed growing rapidly each yea...
Cancer is an increasing global concern, with the number of people diagnosed growing rapidly each yea...
Bacterial nitroreductases are members of a diverse family of oxidoreductase enzymes that are capable...
Bacterial nitroreductases are members of a diverse family of oxidoreductase enzymes that are capable...
Bacterial nitroreductase enzymes, which exhibit the capacity to reduce a wide range of nitroaromatic...
Bacterial nitroreductase enzymes, which exhibit the capacity to reduce a wide range of nitroaromatic...
There is strong interest in developing novel targeted cancer therapies. It has been known for over a...
There is strong interest in developing novel targeted cancer therapies. It has been known for over a...
Specific tumour ablation through gene therapy holds great promise as an anti-cancer strategy. Gene t...