Bioassay-guided investigation of the Tanzanian plant Pyrenacantha kaurabassana for potential anti-HIV-active compounds
- Omolo, J. J.
- Maharaj, V.
- Naidoo, D.
- Klimkait, T.
- Malebo, H. M.
- Mtullu, S.
- Lyaruu, H. V. M.
- de Koning, C. B.
Publication date
January 2012
DOI Publisher
American Chemical Society (ACS) ISSN
0163-3864 Citation count (estimate)
8Abstract
Two new anti-HIV xanthones, 6,7,11-trihydroxy-10-methoxy-9-(7-methoxy-3-methyl-1-oxoisochroman-5-yl)-2-methyl- 12-oxo-12H-benzo[b]xanthene-4-carboxylic acid (1) and 6,7-dihydroxy-10,11-dimethoxy-9- (7-methoxy-3-methyl-1-oxoisochroman-5-yl)-2-methyl-12-oxo-12H-benzo [b]xanthene-4-carboxylic acid (2), and a new hexadecahydrochrysen-3-ol (3) were isolated from the tubers of Pyrenacantha kaurabassana. Compounds 1 and 2 showed moderate anti-HIV activity when tested in the deCIPhR assay on HIV virus type NL4-3, with IC50 values of 21 and 2 mu g/mL, respectively
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