Secondary rapidly menopause after ergometrin abuse - possible side effects ?

U radu je prikazan slučaj nagle prijevremene menopauze u 19-godišnje adolescentice nakon jednokratne višednevne uporabe ergometrina koji je uzimala zbog opetovanih hipermenoragija. Do tada je olihipermenoreje od rane menarche s 10,5 godina liječila kombiniranim estrogensko-gestagenskim pripravcima. Drugih čimbenika nastanka nagle sekundarne hipergonadotropne amenoreje iz osobne i obiteljske anamneze, te laboratorijskom i kliničkom obradom nije se moglo pronaći. Osim akcidentalne uporabe ergometrina, raspravlja se o naglom nastanku sekundarne amenoreje i evidentne ovarijske insuficijencije nakon moguće jake ishemične vazokonstrikcije i nuspojava uporabe ergotalkaloida.The paper presents the case of a sudden early menopause in a 19-year-old adolescent after single use of ergometrine that she had been taking because of repeated hypermenorrhagia. She had been treated for polyhypermenorhoeas of early menarche since the age of 10.5 with combined estrogen-progestin preparations. Other factors for sudden secondary hypergonadotropic amenorrhea from personal and family history and laboratory and clinical treatment could not be found. Apart from the accidental use of ergometrine, sudden emergence of secondary amenorrhea is being discussed and evident ovarian failure following possible strong vasoconstriction and side effects of ergotalkaloid use