Cutaneous Adverse Drug Reactions Induced by Amlodipine.

Kožne nuspojave povezane s korištenjem amlodipina su rijetko opisane. Najčešća kožna reakcija povezana s tim lijekom je pojava flushinga. Ostale kožne promjene, osim pojave urtikarije i eritematoznog makulopapuloznog osipa, koje su najčešće posljedica alergijske reakcije na ovaj lijek, uključuju i pojavu rosacee i fotodistribuirane teleangiektazije, koje zbog slične kliničke prezentacije ne bi smjelo pogrešno dijagnosticirati kao flushing. Iako su spomenute nuspojave većinom blaže do srednje klinički izražene, one uzrokuju značajnu nelagodu u bolesnika i mogu utjecati na terapijsku suradljivost. Osim spomenutih, primjena amlodipina je povezana i s nekoliko ozbiljnih i nepredvidivih kožnih nuspojava koji uključuju vaskulitis uzrokovan lijekovima te pojavu Steven Johnsonova sindroma. Spomenute kožne nuspojave su karakterizirane visokim morbiditetom te čak mogućim smrtonosnim ishodom. Iako su te reakcije općenito rijetke i neuobičajene za primjenu amlodipina, važno ih je identificirati kao moguće reakcije preosjetljivosti uzrokovane tim lijekom.Cutaneous adverse reactions associated with amlodipine have been rarely reported. Its most prevalent cutaneous side effect is fl ushing. Other recognized amlodipine associated skin eruptions, apart from urticaria and erythematous maculopapular rash which are most common allergic reactions, are rosacea and photodistributed telangiectasia which it is important not to misdiagnose as flushing, due to similarities in clinical presentations. Although these are usually mild to moderate skin side effects, they can cause serious discomfort and affect the patient´s treatment compliance. Apart from these mild drug reactions, amlodipine use is associated with other more severe and nonpredictable skin disorders including drug induced vasculitis and Steven Johnson syndrome. These cutaneous adverse drug reactions are characterized with high morbidity and even possible lethal outcome. Although these reactions are in general rare and uncommon in the use of amlodipine, it is important to acknowledge them as a possible hypersensitivity syndrome induced by this drug