ORAL ALLERGY SYNDROME

Oralni alergijski sindrom (OAS) je alergijska reakcija posredovana IgE protutijelima koja se javlja nakon konzumacije svježeg voća i povrća u bolesnika s alergijom na peludi. Simptomi nastaju zbog unakrsne reaktivnosti između peludi i hrane biljnog podrijetla, a koristi se i naziv sindrom alergije na pelud i hranu. Bolesnici su senzibilizirani na alergene peludi i iskazuju alergijsku reakciju na hranu strukturne sličnosti s alergenima peludi. OAS se rijetko viđa u male djece, ali mu učestalost raste s dobi pa je najčešća manifestacija alergije na hranu u adolescenata i odraslih. Simptomi su najčešće lokalizirani u usnoj šupljini, ali se mogu javiti i trbušni simptomi na probavnom sustavu i anafilaksija. Bolesnici u pravilu toleriraju termički obrađenu hranu, iako u onih s atopijskim dermatitisom može doći do pogoršanja ekcema. U slučaju generaliziranih simptoma i anafilaksije savjetuje se strogo izbjegavanje i mjere prve pomoći, uključujući autoinjektor adrenalina.Oral allergy syndrome (OAS) is an IgE antibody-mediated allergic reaction that occurs after consumption of fresh fruits and vegetables in patients with allergy to pollen. Symptoms arise due to cross-reactivity between pollen and plant-derived food and another term used for this syndrome is pollen-food allergy syndrome. The patient is sensitized with pollen and exhibits an allergic reaction to food antigen with structural similarity to the pollen. OAS is rarely seen in young children, but the prevalence increases with age and OAS is the most common manifestation of food allergy in adolescents and adults. Symptoms are usually localized in the oral mucosa, but abdominal symptoms and anaphylaxis may occur as well. Patients generally tolerate thermally processed food, but in those with atopic dermatitis it may lead to worsening of eczema. In the case of generalized symptoms and anaphylaxis, strict avoidance and first aid measures including a self-injectable adrenaline are advised