Pathophysiology of postmenopausal osteoporosis

Osteoporoza je veliki javno-zdravstveni problem jer je direktno povezana s prijelomima. U složenoj patofiziologiji bolesti isprepliću se brojni genetski čimbenici i čimbenici okoline. Navedeni čimbenici određuju vršnu koštanu masu i kasniji stupanj (brzinu) gubitka kosti. U zadnjih nekoliko godina postignut je veliki napredak u poznavanju molekularnih mehanizama izgradnje i pregradnje kosti kao i čimbenika koji su važni za koštanu kakvoću (čvrstoću). Dobro poznavanje patofiziologije postmenopauzalne osteoporoze preduvjet je djelotvorne prevencije i liječenja bolesti.Osteoporosis is a huge public health problem because it is directly related with fractures. A number of genetic and environmental factors are interweaving in the complex pathophysiology. These factors determine peak bone mass and the degree (rapidity) of bone loss later on. Understanding of the molecular mechanism of bone formation and remodeling, as well as understanding of factors responsible for bone quality (strenght) have been significantly improved over the last few years. Thorough knowledge of postmenopausal osteoporosis pathophysiology is the prerequisite for effective prevention and treatment of the disease