[Effect of aminfluoride on diuresis and quanity of xcreted fluoride in rats]

Ispitivanje utjecaj peroralne primjene natrijfluorida, aminfluorida 297 i 335 na volumen urina i količine fluorida u urinu štakora. Izlučene količine fluorida su pri dnevnoj dozi od 1 mgF"/kg kod ženka bile manje prvih mjesec dana pokusa nego kod mužjaka. U daljnjem toku pokusa, kao i pri dnevnoj dozi od 5 mgF/kg količine F u urinu su kod oba spola bile jednake, proporcionalne primljenoj dozi. Volumen urina se kod životinja koje su primile fluoridne preparate u toku pokusa smanjivao. Nastale promjene su vjerojatno posljedica oštećenja bubrega.The effect of peroral application of sodium fluoide, aminfluoride 297 and 335, on the volume of urine and am ount of fluoride in rat urine, was examined. The am ount of fluoride released during daily doses of 1 mgF-/kg was less in females than in males in the first month of trials. In further trials with daily doses of 5 mgF/kg , the am ount of F in urine was the same in both sexes, propotional to the applied doses. The volume of urine in animals which received fluoride preparations was reduced during the trial. Alterations were more than likely due to renal damage