Traditional views on the metabolic derangements underlying insulin resistance and Type 2 diabetes have been largely “glucocentric” in nature, focusing on the hyperglycemic and/or hyperinsulinemic states that result from impaired glucose tolerance. But in addition to glucose intolerance, there is a coordinated breakdown in lipid dynamics in individuals with insulin resistance, manifested by elevated levels of circulating free fatty acids, diminished rates of lipid oxidation, and excess lipid accumulation in skeletal muscle and/or liver. This review examines the premise that an oversupply and/or accumulation of lipid directly inhibits insulin action on glucose metabolism via changes at the level of substrate competition, enzyme re...
AIMS/HYPOTHESIS: It is not known whether the beneficial effects of exercise training on insulin sens...
Type 2 diabetes and obesity epidemics are in effect in the United States and the two pathologies are...
Skeletal muscle constitutes 40% of body mass and takes up 80% of a glucose load. Therefore, impaired...
Traditional views on the metabolic derangements underlying insulin resistance and Type 2 diabetes ha...
During the past half-century, there has been a dramatic increase in the incidence of obesity, insuli...
It is known that excessive systemic lipid availability (as found in obesity) markedly reduces insuli...
It is known that excessive systemic lipid availability (as found in obesity) markedly reduces insuli...
Modest regular exercise and reduction of die-tary fat halves the risk of developing type 2diabetes. ...
The purpose of this review is to provide information about the role of exercise in the prevention of...
Individuals with insulin resistance are characterized by impaired insulin action on whole-body gluco...
The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the ...
The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the ...
Abstract Type 2 diabetes and obesity epidemics are in effect in the United States and the two pathol...
The prevalence of type 2 diabetes mellitus (T2DM) has increased dramatically in the United States ov...
Regular exercise plays a key role in the maintenance of health and physical capabilities. Extensive ...
AIMS/HYPOTHESIS: It is not known whether the beneficial effects of exercise training on insulin sens...
Type 2 diabetes and obesity epidemics are in effect in the United States and the two pathologies are...
Skeletal muscle constitutes 40% of body mass and takes up 80% of a glucose load. Therefore, impaired...
Traditional views on the metabolic derangements underlying insulin resistance and Type 2 diabetes ha...
During the past half-century, there has been a dramatic increase in the incidence of obesity, insuli...
It is known that excessive systemic lipid availability (as found in obesity) markedly reduces insuli...
It is known that excessive systemic lipid availability (as found in obesity) markedly reduces insuli...
Modest regular exercise and reduction of die-tary fat halves the risk of developing type 2diabetes. ...
The purpose of this review is to provide information about the role of exercise in the prevention of...
Individuals with insulin resistance are characterized by impaired insulin action on whole-body gluco...
The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the ...
The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the ...
Abstract Type 2 diabetes and obesity epidemics are in effect in the United States and the two pathol...
The prevalence of type 2 diabetes mellitus (T2DM) has increased dramatically in the United States ov...
Regular exercise plays a key role in the maintenance of health and physical capabilities. Extensive ...
AIMS/HYPOTHESIS: It is not known whether the beneficial effects of exercise training on insulin sens...
Type 2 diabetes and obesity epidemics are in effect in the United States and the two pathologies are...
Skeletal muscle constitutes 40% of body mass and takes up 80% of a glucose load. Therefore, impaired...