Characterisation of Physical-chemical and Self-assembling Properties of Pyridinium Moieties Containing 1,4-Dihidropyridine and Pyridine Derivatives as NADH/NAD Analoques for Development of Gene Delivery Systems

Two main groups of new amphiphiles: derivatives of cationic 1,4-DHP with variations of substituents at different positions of 1,4-DHP cycle and other class, oxidated form, fully aromatised compounds with head-group variations were designed and synthesised as putative delivery agents. All derivatives of cationic 1,4-DHP possess free radical quenching activity and the buffering capacity and the buffering capacity of studied N-unsubstituted 1,4-DHPs were in the pH range 6.8-8.8