Recently, we have shown that down-regulation of methylthioadenosine phosphorylase (MTAP) in hepatocellular carcinoma (HCC) cells enhances the invasive potential and the resistance against cytokines. Here, we aimed at investigating the molecular mechanism underlying this tumor-promoting effect and expanded the analysis to a large series of human HCC tissues. Liquid chromatography tandem mass spectrometry revealed that reduced MTAP expression resulted in higher intra- and extracellular concentrations of 5'-deoxy-5'-methylthioadenosine (MTA) in cultivated HCC cells and, concordantly, higher levels of MTA in HCC tissue. MTA induced matrix metalloproteinase (MMP) and interleukin-8 transcription in HCC cells in vitro, accompanied by enhanced prol...
MTAP (5'-methylthioadenosine phosphorylase) catalyses the reversible phosphorolytic cleavage of meth...
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all ma...
BACKGROUND: Using tissue microarrays, we investigated whether methylthioadenosine phosphorylase (MTA...
The methylthioadenosine phosphorylase (MTAP) gene is localized in the chromosomal region 9p21. Here,...
Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine and adenine salvage pathw...
AbstractMethylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine and adenine salva...
MTAP expression was analyzed by qRT-PCR, Western blot and immunohistochemical analysis. Levels of MT...
To study expression and function of methylthioadenosine phosphorylase (MTAP), the rate-limiting enzy...
Recent studies have shown that a loss of methylthioadenosine phosphorylase (MTAP) gene expression ex...
To study expression and function of methylthioadenosine phosphorylase (MTAP), the rate-limiting enzy...
peer reviewedHomozygous deletions of human chromosomal region 9p21 occur frequently in malignant mel...
The immunosuppressive tumor microenvironment represents one of the main obstacles for immunotherapy ...
The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phos...
[[abstract]]Identification of cancer-associated genes by genomic profiling contributes to the elucid...
Methylthioadenosine phosphorylase (MTAP) is an enzyme involved in the polyamine biosynthesis pathway...
MTAP (5'-methylthioadenosine phosphorylase) catalyses the reversible phosphorolytic cleavage of meth...
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all ma...
BACKGROUND: Using tissue microarrays, we investigated whether methylthioadenosine phosphorylase (MTA...
The methylthioadenosine phosphorylase (MTAP) gene is localized in the chromosomal region 9p21. Here,...
Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine and adenine salvage pathw...
AbstractMethylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine and adenine salva...
MTAP expression was analyzed by qRT-PCR, Western blot and immunohistochemical analysis. Levels of MT...
To study expression and function of methylthioadenosine phosphorylase (MTAP), the rate-limiting enzy...
Recent studies have shown that a loss of methylthioadenosine phosphorylase (MTAP) gene expression ex...
To study expression and function of methylthioadenosine phosphorylase (MTAP), the rate-limiting enzy...
peer reviewedHomozygous deletions of human chromosomal region 9p21 occur frequently in malignant mel...
The immunosuppressive tumor microenvironment represents one of the main obstacles for immunotherapy ...
The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phos...
[[abstract]]Identification of cancer-associated genes by genomic profiling contributes to the elucid...
Methylthioadenosine phosphorylase (MTAP) is an enzyme involved in the polyamine biosynthesis pathway...
MTAP (5'-methylthioadenosine phosphorylase) catalyses the reversible phosphorolytic cleavage of meth...
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all ma...
BACKGROUND: Using tissue microarrays, we investigated whether methylthioadenosine phosphorylase (MTA...